CD44 was identified as a marker for the Hmga2-high state, enabling functional comparison of the two populations. Organoid assays and orthotopic transplantation revealed that SPC-high, CD44-negative ...

为解决急性肾损伤（AKI）机制不明及治疗策略缺乏的问题，南方医科大学研究人员探究 CD44 在 AKI 中的作用。结果发现 CD44 可加重 AKI，抑制它或成治疗新策略。推荐科研读者阅读，以了解 AKI 新机制与潜在疗法。 在当今社会，急性肾损伤（AKI）就像一个隐藏在 ...

(D) Immunofluorescence co-staining of CD4 (red), CD45RO (green ... (H) SBP and UACR of pregnant mice injected with PBS, Sham mouse-derived or RUPP mouse-derived CD4 + CD44 + T cells. Data were ...

As an emerging biomarker, ESRP1 has a decisive impact on the formation and development of solid tumors by regulating the alternative splicing of CD44 and the epithelial-mesenchymal transition (EMT) ...

在生物医学研究的舞台上，实验室小鼠一直是不可或缺的 “主角”。然而，长期生活在特定病原体 - free（SPF）设施笼子里的它们，就像被保护在温室中的花朵，与外界丰富多彩的自然环境隔绝。这使得它们的免疫系统发育与自由生活的哺乳动物相比，存在明显差异，尤其在与人类免疫系统的对比上，这种差异更为突出。比如，实验室小鼠的免疫系统相对人类来说，就像还未完全长大的孩子，不够成熟。

Immunofluorescence (IF) staining was performed as previously described on formalin ... CD3e clone 145–2 C11, CD4 clone RM4-5, CD62L clone MEL-14, CD44 clone IM7, CD8a clone 53–6.7, B220 clone RA3-6B2, ...

The activation and polarization of T cells play a crucial role in atherosclerosis and dictate athero-inflammation. The epigenetic enzyme EZH2 (enhancer of zeste homolog 2) mediates the H3K27me3 ...

Immunofluorescence staining (IF) and Real-Time Polymerase Chain Reaction techniques ... In contrast, CDH18 showed negative correlations with TNFSF14, TNFSF15, PDCD1, TNFRSF14, and CD44, genes reported ...

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This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.