Alpha-actinin can cross-link actin filaments and anchor them to the Z-disk in sarcomeres. Sarcomeres are a structural unit of myofibril in striated muscle. The FATZ (filamin, α-actinin- and ...

Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation. American Journal of Human Genetics , 2021 DOI: 10.1016/j.ajhg.2021.01.013 Cite This Page : ...

Researchers, including some from King's College London, say they now understand why faulty alpha-actinin stops muscles from working properly when people have the heart disease cardiomyopathy.

RUNNING START. World-class sprinters are more likely than their marathon-running counterparts to have alpha-actinin-3 protein at work in their fast-twitch muscles. The gene encodes the protein ...