G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Eutylone, often misrepresented and sold as ecstasy or “molly,” belongs to the synthetic cathinone class commonly referred to as “bath salts.” On its own, the drug poses serious health risks—but when ...

The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled ...

IL-17 comes in six different forms, and there are five different receptors that can bind to it. In their two new papers, the researchers set out to map which of these receptors are expressed in ...

This manuscript presents important findings on a bacterial effector involved in plant symbiotic signaling. The effector proteolytically targets a key receptor while its activity is counteracted by ...

This manuscript describes important findings on a rhizobial effector, its cleavage, and legume receptors involved in symbiosis. The evidence supporting the main claims is solid, though some ...

Nuclear receptors form a family of proteins capable of accommodating a wide variety of small molecules in their ligand binding domain, ranging from therapeutic compounds to endocrine-disrupting ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...

Our brain cells have different types of chemical receptors that work together to produce optimal performance of brain function. Differences in the balance of these receptors can help explain who ...

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . Mol Cancer Ther (2025) 24 (4): 511–522. Androgen receptor (AR) signaling is the ...

Research suggests that eating carrots can boost eye health—but these gains come with caveats. As John Stolarczyk, curator of the virtual World Carrot Museum, told Smithsonian magazine in 2013 ...

A warning on social media said: ‘Multiple samples of beige powder, potentially mis-sold as MDMA, confirmed by Mandrake, to contain synthetic cathinone, 4F-α-PVP, in Manchester. ‘Not much ...