RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

CRISPR-Cas13, a powerful RNA ... This platform combines a catalytically inactive Cas13 enzyme (dCas13) that guides the system to specific RNA targets, with a hyperactive variant of the NAT10 ...

Malic enzymes are widely distributed in nature and have many biological functions. The crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a quaternary complex with NAD+ ...

来自Yu等研究人员开发了基于dCas13-eNAT10融合蛋白的编程化RNA乙酰化系统，首次实现细胞内特定RNA的N4-乙酰胞苷(ac4C)精准修饰。该技术突破传统方法限制，揭示ac4C通过调控转录本亚细胞定位影响基因表达的新机制，为RNA表观遗传学研究提供革命性工具。

Clean energy revolution: Scientists unveil enzyme shaped by nature that could supercharge global biofuel efficiency The discovery came from soil samples hidden beneath sugarcane bagasse, the ...

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