An international team of researchers has uncovered a groundbreaking discovery in the fight against heart disease. They found ...

Effects of VASH1 Knockdown and TTL-E331Q Overexpression on Myocyte Contractility The effect of SVBP depletion was examined in cardiomyocytes from a separate subset of 3 failing hearts (2 HFrEF, 1 ...

You lower into the squat, pause at the bottom, then drive upward to stand; these three phases are called eccentric, isometric and concentric muscle contraction, and if your goal is to build muscle ...

Cardiac muscle function emerges from the coordinated contraction of sarcomeres in cardiomyocytes. Sarcomere dynamics are usually inferred from whole-cell or myofibril observations, assuming ...

Abstract: Adult stem cell derived cardiomyocyte research has been limited by the inability of these cells to fully mature into fully functioning cardiomyocytes. Although these cells exhibit ...

Moreover, heart‐specific CLIP‐170 S311A transgenic mice demonstrated elongation of cardiomyocytes along with accumulated MTs, leading to progressive decline in cardiac contraction. In conclusion, ...

Applying increasing pacing frequencies resulted in decreasing contraction amplitudes without positive staircase effect. Gene expression analysis of selected cytoskeleton and myofibrillar proteins ...

More information: Paula Ortiz-Sánchez et al, Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction, Circulation Research (2019).

Induced loss of SRSF3 in adult cardiomyocytes results in widespread changes in alternative splicing and decapping of mRNAs encoding contraction proteins and its subsequent degradation, leading to ...