It is the presence of cardiomyocytes that results in the early beating of the heart. Cardiomyocytes, or cardiac muscle cells are the main type of heart cells and act as the motor unit to drive heart ...

But in the adult heart, "cardiomyocytes barely divide ... severely impairing heart contraction. To investigate the mechanism through which SRSF3 supports heart contraction, the team compared ...

More information: Paula Ortiz-Sánchez et al, Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction, Circulation Research (2019).

BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

Representative compounds were added to cardiomyocytes in a 1:3 dilution series to determine IC50 values. As before, cardiomyocyte contractions were visualized using the EarlyTox Cardiotoxicity dye ...

How the cardiomyocytes that we start developing ... important structures that help to coordinate sarcomere contraction. These too were greatly disrupted in the mutant myocytes.

But in the adult heart, "cardiomyocytes barely divide ... severely impairing heart contraction. To investigate the mechanism through which SRSF3 supports heart contraction, the team compared ...

"The intracellular effects of focused near-infrared femtosecond laser irradiation are shown to cause contraction in cultured neonatal rat cardiomyocytes. By periodic exposure to femtosecond laser ...

Initially, Taylor’s team reseeded the matrix with neonatal rat cardiomyocytes. In just a few days, the cells transformed into a system capable of contractions. The results were really striking. Around ...