Cardiomyocyte-specific overexpression of various splice isoforms and phospho-isoforms ... First, immunostaining demonstrates that α-adducin is localized to the cytoplasm and membrane only in ...

These mechanisms in conjunction results in increased acetylated YAP accumulation in the cytoplasm. After MI, the cardiac cytoskeleton is stabilized and sequesters cytoplasmic acetylated YAP, which ...

Department of Laboratory Medicine, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen Key Laboratory of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Coordinated cardiomyocyte contraction drives ...

Cells can respond to various signals by changing their internal states. For example, in the nervous system, neurons respond to neurotransmitters to increase or decrease ions and/or chemical mediators ...

Approximately 28 million Americans have been diagnosed with heart disease. 1 Traditional therapies, however, do not fully address every aspect of heart damage, and ...

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is a key player in cardiomyocyte calcium handling and also a classic target in the gene therapy for heart ...

Cardiomyocyte maturation is essential for the generation of robust cardiomyocytes ... The monomeric form (G-actin) of β-actin interacts with MRTFs and retains them in the cytoplasm, inhibiting their ...

MFN2 is a mitochondrial outer membrane fusion protein and Parkin ubiquitination substrate (Gegg et al., 2010). MFN2 is abundantly expressed in the cardiomyocyte cytoplasm and mitochondria and ...