Hypertrophy of heart cells stimulated by pathological stress from cardiovascular disease increases the risk of morbidity and mortality, and inhibition of such hypertrophy is attracting increasing ...

In the rat, mouse, dog, and human heart, connexin40 is abundant in the atrioventricular conduction system, ie, the His bundle, bundle branches, and Purkinje fibers, where it is implicated in ...

In comparison to 430 genes with H3K9Ac enrichment observed in DMSO-treated cells, which were mainly involved in cardiac muscle contraction (Fig. 7G and H), 2C treatment markedly enhanced the ...

Duchenne muscular dystrophy (DMD) is a severe X-chromosomal disease characterised by progressive muscle weakness and degeneration. Cardiac involvement is inevitable in DMD patients and ventricular ...

Cardiac conduction is traditionally understood to follow a cable-like model of electrical conduction. 1–4 In this paradigm, electrical current is envisaged as flowing into myocytes, through gap ...

Cardiac prophylactic treatment began before age 14 for 27.7% of the cohort. Compared with patients not treated prophylactically, treatment was associated with a 54% reduction in death.

Activated T cells may mistakenly identify certain antigens in the cardiac conduction system as tumor antigens, leading to cross immune attacks. Johnson et al. also observed necrosis and infiltration ...