Deregulation of the cell cycle commonly occurs during tumour development, resulting in unrestricted cell proliferation (Sherr, 1996; Lundberg and Weinberg, 1999; Owa et al, 2001). Cyclin-dependent ...

Although Q deprivation causes G1 cell cycle arrest in non-transformed cells, its impact on the cancer cell cycle is not well characterized. ... capecitabine and paclitaxel.

During the first cycle of capecitabine development, three concomitant drugs were found to affect 5-FU clearance. [5] Paracetamol and morphine increased 5-FU clearance by 26% and 41%, respectively ...

Anticancer efficacy of natural withanolides in triple-negative breast cancer through down regulation of BRCA1, cell-cycle arrest, and induction of apoptosis. Background: Recent data suggest that ...

Definitive concurrent chemoradiotherapy (DCRT) is the standard treatment for inoperable locally advanced esophageal squamous cell carcinoma. Considering the adverse events in DCRT and the unclear ...

We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced esophagogastri ...

Cyteir Therapeutics, Inc. (“Cyteir”) (Nasdaq: CYT) today presented ongoing results from a dose expansion cohort in its Phase 1 combination study of CY ...

Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend survival rate by nearly 10%. However, recent studies revealed that almost 50% of patients develop ...

If you are in group 2, you have gemcitabine in the same way as group 1, and you have capecitabine tablets to take at home on days 1 to 21 of each treatment cycle. The doctors will ask you to fill in a ...