Deregulation of the cell cycle commonly occurs during tumour development ... The combination of indisulam with capecitabine showed additive effects in preclinical studies when both agents were ...

Our study provides proof-of-principle that cancers with specific genetic defects and dysregulated metabolic cell cycle checkpoints ... cells became sensitive to capecitabine and paclitaxel.

Not surprisingly single agent fluoropyrimidine therapy was more favorably tolerated over combination chemotherapy and for select patient's single agent capecitabine may represent an alternative to ...

Anticancer efficacy of natural withanolides in triple-negative breast cancer through down regulation of BRCA1, cell-cycle arrest, and induction of apoptosis. Background: Recent data suggest that ...

During the first cycle of capecitabine development, three concomitant drugs were found to affect 5-FU clearance. [5] Paracetamol and morphine increased 5-FU clearance by 26% and 41%, respectively ...

We evaluated capecitabine (an oral fluoropyrimidine ... if they had a histologically proven adenocarcinoma, squamous-cell carcinoma, or undifferentiated carcinoma of the esophagus ...

Capecitabine is a chemotherapy drug used for ... "In addition, in human cell cultures, CDH4 down-regulation resulted in the reduced expression of involucrin, another skin protein that is essential ...

If you are in group 1, you have gemcitabine through a drip into a vein on days 1, 8 and 15 of each treatment cycle. If you are in group 2, you have gemcitabine in the same way as group 1, and you have ...