As calcium mediates multiple signalling pathways and gene expression, we investigated the transcription profile in PMCA4 −/− fibroblasts. Using an Affymetrix microarray GeneChip technology, we ...

"Until recently, those stimuli were thought to activate two distinct calcium-dependent signaling pathways in the heart that ultimately lead to hypertrophy. One of them is called the calcineurin ...

New potential therapy for cardiac hypertrophy. ... Biplab Das. Inhibiting the activity of a specific calcium-regulating membrane protein may prevent the thickening of heart muscle tissues, ... The ...

Previous studies showed that calcium plays an important role in cardiomyocyte proliferation. In the current study, Abouleisa ...

Drugs that inhibit L-type calcium channels (LTCC) like nifedipine have long been used to treat hypertension, but preliminary research conducted by two separate groups had previously hinted that ...

It is often a reversible process that does not cause serious effects on the structure or function of the heart, but if the factor causing cardiac overload becomes chronic, it can lead to ...

It is often a reversible process that does not cause serious effects on the structure or function of the heart, but if the factor causing cardiac overload becomes chronic, it can lead to ...

Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity. npj Regenerative Medicine , 2025; 10 (1) DOI: 10.1038/s41536-025-00389-z ...

In this study, we show that pharmacological protein kinase C (PKC) activation induces cardiomyocyte hypertrophy via activation of novel PKC isoforms. Both neonatal rat ventricular cardiomyocytes and ...

Cardiomyocyte hypertrophy indexes (i.e., single-cell surface area, left ventricular fibrosis area, ... HNP-1 treatment may reverse HLVH by inhibiting NF-кB signaling pathways.