Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation ... Abouleisa and her colleagues’ research highlights the importance of targeting ...

This phenomenon is essential for functioning heart tissue. Unexpectedly, the researchers noticed that the cells processed calcium more effectively due to an upregulation of genes involved in ion ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit flies and another important for the growth of embryos -- interact in embryonic mouse hearts to restrict cell ...

However, the functional role of cardiomyocyte-derived BDNF in heart pathophysiology is not yet fully known. Recent studies revealed that BDNF-TrkB pathway plays a critical role to maintain integrity .

Studies have shown that MI/R injury can cause calcium overload that can further aggravate MI/R injury. Therefore, we reviewed the effects of critical calcium pathway regulators on MI/R injury and drew ...

NCX indicates sodium/calcium exchanger; SERCA-2a, sarcoplasmic reticular ATPase. It is unclear whether PP-1 may affect pathways other than PLB/SERCA2a, such as NCX, Bcl-2, or other pathways associated ...