The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Nat. Commun. 7:11074 doi: 10.1038/ncomms11074 (2016).

The discovery by a team at the Victor Chang Cardiac Research Institute in Perth, Australia, showed that the molecule Piezo1 initiates the cardiomyocyte hypertrophic ... stimuli were thought to ...

Inhibiting the activity of a specific calcium-regulating membrane protein may prevent the thickening of heart muscle tissues, a disorder known as cardiac hypertrophy, a new study finds 1. This insight ...

dysregulation of calcium-handling proteins, metabolic alterations, cardiomyocyte hypertrophy and cell death. Fibrosis and inflammation are key factors in the progression of this pathological ...

Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation ...

When compared to previously published models of stretched neonatal rat ventricular myocytes and human embryonic stem cell-derived cardiomyocytes, hiPSC-CMs displayed more pronounced enrichment of ...

Another study revealed that insulin can activate the SPEG-SERCA2a pathway through the protein kinase B (PKB) in the heat, which in turn regulates cardiomyocyte calcium homeostasis. However ...

Targeted genomic approaches (such as gene knockout/knockdown) can then be carried out in an iPSC-derived cardiomyocyte model of hypertrophy to better define the roles of individual factors in cardiac ...

In this study, we show that pharmacological protein kinase C (PKC) activation induces cardiomyocyte hypertrophy via activation of novel PKC isoforms. Both neonatal rat ventricular cardiomyocytes and ...

Cardiomyocyte hypertrophy indexes (i.e., single-cell surface area, left ventricular fibrosis area, ... HNP-1 treatment may reverse HLVH by inhibiting NF-кB signaling pathways.