在佛罗里达的晨光中，72岁的心脏病患者玛丽莲习惯性地将降压药与鲜榨葡萄柚汁一同服下。这个延续了二十年的早餐仪式，却在一个月前令她因药物中毒被紧急送医——这背后，正是葡萄柚中神秘的呋喃香豆素在作祟。如今，以色列科学家手握基因密码，试图终结这场持续了半个 ...

Like pretty much all fruits and vegetables, grapefruit can help improve your health in many ways. It’s packed with vitamins, minerals, antioxidants and other plant compounds that do a body good. Let’s ...

Eplerenone has an elimination half-life of 4 6 hours. Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir. About 50% is bound by plasma protein.

According to the National Capital Poison Center, a not-for-profit poison control organization, at least 85 drugs—including ...

Submission supported by positive results from global, Phase 3 4WHIM clinical trial;U.S. regulatory approval in WHIM syndrome granted in ...

Zytiga 的作用原理是减少体内雄激素的产生。雄激素是一种可以促进前列腺肿瘤生长的男性荷尔蒙。Zytiga 与类固醇药物（泼尼松或甲基泼尼松龙）一起使用，用于治疗已扩散到身体其他部位的前列腺癌。Zytiga ...

Exelixis, Inc. (Nasdaq: EXEL) today announced results from a subgroup analysis of the phase 3 CABINET pivotal study of ...

Rigel Pharmaceuticals, Inc.  today announced the first patient has been enrolled in a Phase 1 study evaluating the safety and tolerability of escalating doses of fostamatinib, the company's oral ...

如果 CYP3A4 酶的活性被抑制，会导致这些药物在体内的代谢减少，使药物在血液中的浓度升高，从而增强药物的作用和副作用，可能对人体造成损害。 不同的药物受到的影响不尽相同。但总体来说，呋喃香豆素可以使药物以 2～10 倍的量进入血液。

因此，在治疗期间，建议限制咖啡因的摄入，以保护药物的疗效。有饮茶习惯的患者在服用药物的 前后2小时内，应 避免饮茶，且避免饮用浓茶。

Pfizer Inc. (NYSE: PFE) today announced positive results from the Phase 3 BREAKWATER trial evaluating BRAFTOVI® (encorafenib) in combination with cetuximab (marketed as ERBITUX® ) and mFOLFOX6 ...

在使用艾伏尼布治疗复发性或难治性急性髓系白血病（AML）成人患者之前，必须确定患者骨髓或外周血中具有异柠檬酸脱氢酶-1（IDH1）突变。应采用充分验证过的检测方法确定患者的IDH1突变状态。经医院或实验室的IDH1突变检测结果判断为携带IDH1突变的 ...