结果表明，cyp2c8 和 cyp3a 的活性是图卡替尼在个体捐赠者人肝微粒体中表观清除率的重要预测指标。 综合研究结论和讨论部分，该研究意义重大。 它明确了 CYP2C8 和 CYP3A 表型与图卡替尼代谢个体差异之间的紧密联系，这为后续研究提供了重要框架。

在药物研发领域，cyp3a酶介导的药物-药物相互作用（ddis）一直是悬在研究人员头顶的"达摩克利斯之剑"。作为人体最重要的药物代谢酶，cyp3a参与了约50%临床药物的代谢过程，其活性受诱导或抑制可能导致严重的临床后果。

Kratom faces scrutiny over health risks 02:18. Nearly 2 million Americans in 2021 used the herbal supplement Kratom to treat pain, anxiety and opioid withdrawal, according to the Food and Drug ...

Millions of Americans use kratom, which is sold at gas stations, vape shops and bars. It can act like an opiate on the body. The FDA warns against using kratom, but most states don't regulate it.

Kratom is a plant that grows in Southeast Asia. Some people take it for its stimulant or opioid-like effects. Learn about the possible risks in this article.

The benefits of kratom have not been shown in research. And it carries risks, including dependence. It’s legal, but not regulated — the supplement you buy could contain other harmful ...

The National Institute on Drug Abuse notes that deaths from overdosing on kratom seem to be “extremely rare”: A 2019 study cited 11 deaths in the U.S. between 2011 and 2017 that were linked to ...