Cis activation increases transgene expression in fibroblasts ... We also constructed a ‘super-enhancer’ vector (AV.SupEnh), which contains SV40 and CMV enhancers but no promoter or transgene ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

Mechanistically, the DNA double-strand break (DSB) sensors MRE11, RAD50, and NBS1 (MRN complex) remained intact, but both expression and activity of the DNA damage checkpoint kinase ...