Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without ...

Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

In a recent study, Dr. Jennifer Lund, a professor in the Vaccine and Infectious Disease Division, and her team demonstrated that bystander-activation of memory CD8 T cells during Herpes Virus 2 (HSV-2 ...

In response, the T cells activate and make copies of themselves ... A variant form of LGL leukemia involves a specific T cell called CD8+. CD8+ T cells are T cells that carry the co-receptor ...

In a human-mouse xenogeneic GvHD (xGvHD) model, ALTB-268 significantly improved survival, reduced disease severity score and body weight loss, and decreased human CD4+ and CD8+ T cells, while ...

Findings indicate that frequent COVID-19 booster shots do not weaken T-cell responses, alleviating concerns for vulnerable ...

Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

If antigen binding does not impact T-cell receptor structure, how does it trigger T-cell activation? The research team suggest that the CD8 receptor may also play a crucial role, by phosphorylating ...

Initial data demonstrate a highly differentiated clinical pharmacodynamic profile with unprecedented levels of selective CD8+ T cell activation as well as initial evidence of anti-tumor effect ...

While Halters is still piecing together the mechanisms underlying these effects, he thinks something about the activation of the brain endothelium in ApoE4 carriers seems to play a hand in easing the ...

They recognize pathogens and secrete cytokines that activate other immune cells, including CD8+ T cells. However, they have no direct involvement in attacking and neutralizing pathogens.