Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

董晨教授团队在 Nature Communications 期刊发表了题为：TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8 + T cell activation 的研究论文。

In a recent study, Dr. Jennifer Lund, a professor in the Vaccine and Infectious Disease Division, and her team demonstrated that bystander-activation of memory CD8 T cells during Herpes Virus 2 (HSV-2 ...

In a human-mouse xenogeneic GvHD (xGvHD) model, ALTB-268 significantly improved survival, reduced disease severity score and body weight loss, and decreased human CD4+ and CD8+ T cells, while ...

Study: GZMK-expressing CD8+ T cells promote recurrent airway ... may also facilitate the recruitment of myeloid cells, thereby leading to activation of type 2 effectors. High GZMK levels were ...

Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

we figured that a memory T cell in its natural habitat would encounter environments with different TGF-β concentrations at different times before or after activation, so we sought a system that could ...

They recognize pathogens and secrete cytokines that activate other immune cells, including CD8+ T cells. However, they have no direct involvement in attacking and neutralizing pathogens.

In response, the T cells activate and make copies of themselves ... A variant form of LGL leukemia involves a specific T cell called CD8+. CD8+ T cells are T cells that carry the co-receptor ...

Initial data demonstrate a highly differentiated clinical pharmacodynamic profile with unprecedented levels of selective CD8+ T cell activation as well as initial evidence of anti-tumor effect ...

It could also go both ways, he said. While Halters is still piecing together the mechanisms underlying these effects, he thinks something about the activation of the brain endothelium in ApoE4 ...