To determine whether the influence of Tet1/3 on CD8 effector fates stems from thymic programming of gene targets regulating effector T-cell differentiation or from their requirement during T-cell ...

黑色素瘤：cd8 + t 细胞密度、pd-l1 表达等是黑色素瘤预后的生物标志物。zeb1 的表达与 cd8 + t 细胞浸润减少有关，靶向 zeb1 可能增强免疫治疗效果。针对 csc 的疫苗可促进 dc 成熟，激活 cd8 + t 细胞，抑制黑色素瘤生长和转移。

具体而言，研究显示在 cd8 + t 细胞活化过程中，其染色质三维结构经历了显著的重塑，a/b 区域中有 6.9%、拓扑关联域中有 24% 以及染色质环中有 85% 的 ...

Find out what you need to know about the CD4:CD8 ratio test. Learn why your doctor asks for it, what information they get from it, and what it means for you.

The key finding is that immunoregulatory properties of tumor infiltrating/resident CD56-bright NK cells (assumed to be non-cytotoxic) are beneficial for outcome through cross-talk with DC and ...

Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase ... CCL5 is pro-inflammatory and an acute response to ...

Given that Lrp10 suppressed IL7R during normal CD8 T-cell homeostasis, we next compared IL7R levels on CD8 T cells in tumors from Lrp10 +/+ and Lrp10 −/− mice to those from the spleen (Fig. 4E).

BACKGROUND: Aldosterone has been described to initiate cardiovascular diseases by triggering exacerbated sterile vascular inflammation. The functions of CCL5 (C-C motif chemokine ligand 5) and its ...

Aldosterone has been described to initiate cardiovascular diseases by triggering exacerbated sterile vascular inflammation. The functions of CCL5 (C-C motif chemokine ligand 5) and its receptor CCR5 ...

撰文 | 风. CD8+T细胞介导的适应性免疫应答是机体抗感染和抗肿瘤的重要保护机制。当外来抗原入侵后，树突状细胞 （DC） 被激活成为成熟 （mature） 状态，之后抗原提呈给相对应的初始CD8+T （naive） 细胞完成扩增和分化过程以清除抗原。 有趣的是，早在上世纪80年代，学者已经发现DCs也需要接收CD4+T ...