结果表明ccl5由癌细胞表达，cxcl9却由癌症中的免疫细胞产生，并且当癌细胞减少ccl5的表达时，cxcl9的表达也会下降，随之导致癌症中cd8+ t细胞的数量逐渐减少。这种表达降低的机制属于表观遗传沉默，与抑制其靶基因表达的dna化学修饰有关。 癌细胞通过抑制ccl5 ...

The observed production of chemokines such as CCL5, CXCL9 and CXCL10 by tumoral eosinophils raised the possibility that CD8 + T cells might be attracted into the tumor by these chemoattractants ...

Cancer cells have good reason to suppress CCL5: it attracts CD8+ T cells. The researchers show that when T cells drawn by CCL5 reach the tumor and are activated by cancer antigens, ...

In the current study, Coukos and his team identified two chemokines, CCL5 and CXCL9, that are consistently associated with CD8+ T cell infiltration of solid tumors.

A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill ...