This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer ...

Additionally, local inflammation initiates the production of chemokines and the recruitment of immune cells, including CD8 + T cells. However, how the recruited immune cells and the chemokine system ...

Comprehensive transcriptomic, epigenomic, and flow cytometric profiles of primary CD8+ T cell subsets implicate T cell exhaustion in pathophysiology. We show that T cells in ME cases are ...

A variant form of LGL leukemia involves a specific T cell called CD8+. CD8+ T cells are T cells that carry the co-receptor CD8. A co-receptor is a surface protein that makes antigen receptors more ...

This important study extends our understanding of how regulatory T cells can modulate the function of effector CD8 T cells. The evidence supporting the claims of the authors is solid and direct test ...

Researchers have found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung-resident alveolar macrophages (AMs). This interaction ...

Heart-tropic chemokines expressed by Temra CD8 + cells such as CCL5 may become important therapeutic targets in the prevention and treatment of ICI myocarditis and other types of pathological cardiac ...

1 Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands 2 Center for Translational Immunology, University Medical Center Utrecht ...

研究人员发现趋化因子CCL5和CXCL9与实体瘤中的CD8+ T细胞浸润有关，并且具有CCL5和CXCL9共表达的肿瘤患者具有更长的存活期，以及对免疫检查点阻断治疗更敏感。 近期的Cancer Cell发表了一篇题为“Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and ...

先前的研究证实，具有肿瘤清除作用的免疫 T 细胞需要与肿瘤细胞对好“暗号”后，才能打入肿瘤组织内部，但具体如何进行这种至关重要的信息交流，以及依赖哪些分子进行交流，科学家不得而知。因此，了解这一过程对于临床治疗实体肿瘤意义非凡。

这项研究发表在最新一期的《Cancer Cell》杂志上 ... 的团队发现了两种趋化因子，CCL5和CXCL9，它们与实体肿瘤的CD8+ T细胞浸润一致相关。