Figure 1: Varying the antigen dose affects the magnitude of the CD8 + T cell response and the recruitment of naïve CD8 + T cells, but all recruited cells divide extensively. Figure 2: CD8 + T ...

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8 + T cell exhaustion Blockade of alternative T cell checkpoint molecules, such as Tim3, is a promising alternative to inhibition ...

中CD69+CD103+病毒特异性CD8+ T细胞与肺TRM细胞的动态关联，发现CCR5-CCL5轴介导的肺-dLN逆向迁移对维持呼吸道记忆T细胞库至关重要，为优化局部抗感染免疫应答提供新靶点。 在抵御病原体入侵屏障组织的过程中，组织驻留记忆T细胞(Tissue-resident memory T cells, T RM ...

Scientists found that MGAT1 does this by influencing another molecule, CD73, which prevents immune cells—specifically CD8 + T cells—from effectively killing the cancer cells. Normally ...

本研究揭示了CD8+ T细胞通过表达CD40L（CD40配体）直接诱导CD40+肿瘤细胞死亡的创新机制。研究人员发现，CD40L+CD8+ T细胞通过激活caspase-8触发非经典细胞毒性，显著抑制肿瘤生长。该发现为增强免疫疗法疗效提供了新靶点，尤其在肾细胞癌（RCC）中，CD40信号抵抗 ...

CAR-T cell therapy, which involves genetically engineered T-lymphocytes targeting cancer cells, has shown high efficacy in blood cancers and is being explored for solid tumors and autoimmune diseases.

Researchers conducted this observational study to investigate the safety of CD19-targeting CAR T-cell therapy in patients with autoimmune diseases. They included 39 patients (median age ...

在呼吸道抵御流感病毒、新冠病毒等病原体侵袭的免疫前线，驻留记忆T细胞（Tissue-resident memory T cells, ...

Candid's T-cell engager shopping spree rolls on with WuXi Biologics pact worth up to $925M As for Juri, very little is publicly known about the TCG Labs Soleil-created company.

The human trial news comes on the back of four years of preclinical research and aims to have broad application that doesn't require harvesting cells from a patient but offer a "one size fits all ...