A, The hidden, dynamic nature of the spindle.The spindle contains different subpopulations of microtubules — kinetochore microtubules (1), interpolar microtubules (2) and astral microtubules (3).

The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and ...

To better understand the role of kinesin-8 proteins in mitosis, we have studied the effects of deletion of the fission-yeast kinesin-8 proteins Klp5 and Klp6 on chromosome movements and spindle length ...

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast. Published:1/20/2017 1/20/2017 . Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, ... Bipolar ...

The mitotic spindle includes thousands of microtubules, ... "This is a way by which the cell can tune the amount of force it needs in order to build a nice balanced spindle structure," Forth says.

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare ... “This is a way by which the cell can tune the amount of force it ...

In research published October 1 in Developmental Cell, scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation ...

Constructing a body is like building a house—if you compromise structural integrity, ... A flip of the mitotic spindle has disastrous consequences for epithelial cells.

view more KANSAS CITY, MO—Constructing a body is like building a house—if you compromise ... of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes ...