The discovery that FANCM’s domains physically interact suggested they might functionally cooperate in migrating these branched DNA structures. To test this, we developed a novel real-time assay using ...

For PK analysis of mRNAs, the hybridisation-based Branched DNA assay, also known as the BDNA assay, relies on signal amplification technology to detect nucleic acid molecules.

To realize an efficient hybridization of oligonucleotides, a DNA self-assembled monolayer (SAM) composed of branched probe DNA containing single- and double-stranded portions was prepared on a gold ...

Hepatitis B virus (HBV) infection remains a major global health concern, necessitating the development of sensitive and reliable diagnostic methods. In this study, we propose a novel approach to ...

The CUTANA® meCUT&RUN assay uses a novel methyl-DNA binding fusion protein to specifically enrich 5-methylcytosine (5mC) with base-pair precision. This method detects over 80% of methylated CpGs ...

Assessing a tumor-agnostic circulating tumor DNA assay for uveal melanoma surveillance and metastatic disease monitoring. Emily Gordon, Diana McDonnell, Shaheer Khan, Brian P. Marr Journal of Clinical ...

Tissue-free circulating tumor DNA assay and patient outcome in a phase III trial of FOLFOX-based adjuvant chemotherapy (Alliance N0147). Diana I. Segovia, Aaron Hardin, Thereasa A. Rich, Steven R.

Genomic and epigenomic patterns within DNA molecules are pivotal for a broad spectrum of in-vitro diagnostic applications, including companion diagnostics (Fridlyand et al, 2013; Van Neste et al, 2011 ...

Currently, several technologies have been developed for HCV RNA detection, such as branch DNA assay, real-time quantitative polymerase chain reaction coupled with reverse transcription (RT-qPCR), ...

The Ho was highest in the Tongjiang goat at 0.2931, whereas the Chengdu grey goat had the lowest Ho at 0.2507. The He of six goat populations was remarkably similar (Supplementary Table S5).Conversely ...