Further studies have shown that the expression of the key autophagy regulator protein Beclin 1 is reduced in early AD, suggesting a connection between autophagy dysregulation and AD. Although a large ...

Regulating membrane protein abundance through Lysosome Targeting Chimera (LYTAC) holds significant promise in addressing various diseases. However, the precise structural control of LYTAC molecules ...

Introduction. The pathogenesis of acute pancreatitis (AP) is complex and multifactorial and has not been fully elucidated. Impaired autophagy, abnormal activation of trypsinogen, and the increased ...

Figure 1.Loss of autophagy activity suppresses the retarded heterochronic defects in miRISC mutants. (A) Schematic illustration of seam cells in a wild‐type L1 larva.(B) Division pattern of seam cells ...

These show that Hy-Exos may regulate autophagy in IBD. Research has demonstrated decreased expressions of LC3II/I and beclin 1 in colitis (148, 149). Hence, Hy-Ex upregulates LC3II/I and beclin 1, ...

The method involves fixation of tissues, typically in formalin, followed by paraffin embedding, sectioning, and staining. Specific primary antibodies targeting autophagy markers such as LC3, Beclin-1, ...