1 Department of Hepatobiliary Surgery, The Seventh People’s Hospital of Chongqing, Chongqing, China; 2 Department of Hepatobiliary Surgery, District Traditional Chinese Medicine Hospital, Chongqing, ...

Beclin-1-mediated autophagy acts as a molecular switch that governs the early uterine morphogenetic program by maintaining the endometrial progenitor stem cells.

综上所述，铁死亡与SCIRI密切相关。USP11和Beclin 1之间的相互作用是触发自噬激活、促进自噬铁蛋白降解和导致铁下垂的关键分子事件。了解铁死亡的分子机制和信号通路可能为调控SCIRI后神经细胞的存活和死亡提供新的诊断和治疗方法。 该研究结果强调了USP11介 ...

In addition, the molecule did not disrupt the Beclin 1–UVRAG interaction, critical for VPS34 Complex II, and thus had little impact on vesicle trafficking. This molecule is a promising new tool that ...

Autophagy is a tightly regulated catabolic process wherein cells under stress sequester ... structures is the recruitment and activation of the class III phosphatidylinositol 3-kinase complex ...

the binding of Bcl-2 (a negative regulator of autophagy) to Beclin 1 (an allosteric modulator of the Beclin 1/VPS34 lipid kinase complex that functions in autophagy initiation). These assays use ...

LPS induced a dose-dependent increase in autophagy at low doses, followed by a decline that was in conjunction with mammalian target of rapamycin activation at high doses. Cardiac-specific ...

Beclin 1 is an essential autophagy protein. Through its coiled-coil domain, Beclin 1 recruits two modulators, Atg14L and UVRAG, to form Atg14L- or UVRAG-containing Beclin 1–Vps34 subcomplexes ...

Here we show that two related stress-responsive kinases, members of the p38 mitogen-activated protein kinase (MAPK) signaling pathway MAPKAPK2 (MK2) and MAPKAPK3 (MK3), positively regulate ...

Cancer Discov (2013) 3 (11): OF8. EGFR activation suppresses autophagy and promotes NSCLC growth via Beclin 1 phosphorylation. Major finding: EGFR activation suppresses autophagy and promotes NSCLC ...