更棘手的是，RA滑膜组织中纤维母细胞样滑膜细胞(FLSs)的恶性增殖与自噬(Autophagy)-凋亡(Apoptosis)平衡紊乱密切相关——这种失衡被证实与高迁移率族蛋白1(HMGB1)过表达及Beclin 1-Bcl-2复合体结合减少直接相关，但具体调控机制尚未阐明。

Autophagy is the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier cells. It allows your body to remove the dysfunctional cells.

The tier 1 capital ratio is the ratio of a bank’s core tier 1 capital—its equity capital and disclosed reserves—to its total risk-weighted assets.

Currently, the national average rate on a 12-month CD, according to data from the FDIC, is 1.62% as of June 2025, but the best one-year CD rates today top 5.00% APY.

Find out the full results for all the drivers for the latest Formula 1 Grand Prix on BBC Sport, including who had the fastest laps in each practice session, up to three qualifying lap times ...