Autophagy is tightly regulated by the activity of the Beclin 1 complex in initiating the formation of autophagosomes. 16 We therefore compared Beclin 1 expression in mammospheres and in adherent ...

Pooja Popli et al. Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.

8月24日，中山大学潘志忠，林俊忠和彭健宏共同通讯在《Autophagy》在线发表 ... 作用被认为是自噬体成熟的促进子，BECN1 / Beclin 1是该途径的主要 ...

更棘手的是，RA滑膜组织中纤维母细胞样滑膜细胞(FLSs)的恶性增殖与自噬(Autophagy)-凋亡(Apoptosis)平衡紊乱密切相关——这种失衡被证实与高迁移率族蛋白1(HMGB1)过表达及Beclin 1-Bcl-2复合体结合减少直接相关，但具体调控机制尚未阐明。

蛋白Beclin-1通过调节自噬(一种消化和循环细胞成分的自然过程)来控制动物模型中的子宫内膜重塑和妊娠的建立。 在女性的整个生育过程中，子宫内膜(子宫内膜)会经历周期性的重塑。它在月经周期增厚，为胚胎着床做准备，在 ...

USP11 通过去泛素化 Beclin 1 ... Yuluo Rong et al. USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1.

The Beclin 1–interacting complex, a regulatory platform, consists of Beclin 1, BCL-2 family proteins (which inhibit autophagy), the class III phosphatidylinositol 3-kinase (VPS34), and ATG14L ...

Protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy, a natural process that digests and recycles cellular components.

Beclin-1-mediated autophagy acts as a molecular switch that governs the early uterine morphogenetic program by maintaining the endometrial progenitor stem cells.

Importantly, restoring only Beclin-1-driven autophagy, but not apoptosis, promoted normal uterine remodeling. "After birth, the uterus goes through a multistep process of development that is ...

“We also studied the mechanism by which Beclin-1 regulates uterine development,” Kommagani said. “Beclin-1 is known to regulate two distinct natural processes called autophagy and apoptosis that help ...