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斑马鱼胚胎发育毒性评估:5-羟基-3,7,4'-三甲氧基黄酮(5HTMF)的安全 ...
为解决类风湿性关节炎(RA)治疗中潜在药物毒性的问题,研究人员针对从Cleome gynandra L.中分离的黄酮类化合物5HTMF开展斑马鱼胚胎发育毒性研究。结果显示,5HTMF在100 μM浓度下仅引起20%胚胎尾部轻微异常,且无显著肝毒性,而地塞米松(10 μM)导致61.11%胚胎尿囊 ...
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