The structures of the isolated compounds were deduced mainly from 1 H and 13 C NMR spectroscopic data at 300 and 75.4 MHz, respectively, with the aid of 1 H, 1 H-COSY, 13 C, 1 H-COSY-1 J (CH) and 13 C ...

The new license, which includes both method of use claims and compound structures, significantly extends Trethera’s patent protection in the world’s largest pharmaceutical markets. When combined with ...

In chemistry and drug discovery, compound promiscuity is a controversial issue and often viewed differently. On the one hand, promiscuity has a clear-cut negative connotation, as promiscuous behavior ...

The estrogenicities of 10 compounds found as impurities in industrial grade bisphenol A (BPA) were measured by yeast two-hybrid assays incorporating the human estrogen receptor α (hERα) or the medaka ...

A further series of compounds derived from an arylpyrazole structure was reported in 2006. 82 These compounds bind the glucocorticoid receptor with specificity and relatively high affinity ...