CartiLife is indicated for the treatment of knee cartilage defects. CartiLife is under development for the treatment of articular cartilage defects. The drug candidate comprises of pellet-type ...

We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...

Background: Loss of articular cartilage is one of the major signs of osteoarthritis (OA). Aggrecan, the main proteoglycan component of the extracellular matrix of articular cartilage is cleaved by ...

Hyaline cartilage consists of round chondrocytes, which are cells that produce collagen, embedded within a dense extracellular matrix (ECM). This ECM acts as a physical scaffold ... is to provide an ...

Articular cartilage was separated from the femoral heads of mice ... characterized by a marked increase in glycosaminoglycan depletion within the extracellular matrix and more advanced cartilage ...

Such data somewhat support the aforementioned hypothesis. Meanwhile, our understanding of the extracellular matrix (ECM) has changed considerably over the last decade. A lot of studies have bit by bit ...

Cartilage’s biomechanical properties – it is strong but flexible – are due to cells called chondrocytes secreting large amounts of collagen-rich extracellular matrix (ECM), which surrounds ...

These particles, called extracellular vesicles, are considered attractive vehicle models for new drug therapies. But until now, researchers haven't had the complete picture of how they work.

Cartilage comprises two major components, the extracellular matrix (the surrounding proteins that provide structure) and chondrocytes, the resident cell population. In OA, the health of both these ...

Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an 710032, ...