Apoptin is derived from chicken anemia virus (1), which has two nuclear localization signals. These signals can help Apoptin to specifically enter tumor cells’ nuclei and interact with the APC1 ...

Oncolytic virotherapy is emerging as an important agent in cancer treatment. In a previous study, we designed and constructed Ad-Apoptin-hTERTp-E1a (Ad-VT), a dual cancer-selective anti-tumor ...