Midlife cardiometabolic profiles were differentially associated with risk for early- and late-onset dementia regardless of genetic predisposition.

研究结论和讨论部分指出，APOE4 在小胶质细胞中的病理作用可能是通过损害自噬以及相关的 Aβ 斑块清除能力来实现的。这一发现揭示了 APOE4 与小胶质细胞自噬活性之间的直接联系，意味着可以通过诱导自噬的药物治疗来对抗 APOE4 的病理影响，例如雷帕霉素。这为 APOE4 相关的 AD 脑部病理治疗提供了新的思路和潜在的治疗方法，有望为 AD 患者带来新的希望。

Secondary endpoints in the MINDFuL trial include the CDR-SB, E-Cog, ADL and Neuropsychiatric Inventory (NPI) instruments, ...

2025 年 3 月 31 日，复旦大学附属华山医院神经内科和首都医科大学宣武医院暨国家神经疾病医学中心传来消息， 全球首款每月仅需注射 1 次的阿尔茨海默病治疗新药——多奈单抗注射液（Donanemab Injection）——在国内正式开打。

Lilly said it is planning to request a re-examination of the CHMP's appraisal of Kisunla, pointing out that the drug has ...

【华山医院开出礼来AD药首方 ...

A LANDMARK genome-wide association study of 1,483 Lewy body disease (LBD) cases has identified APOE ε4 as the strongest ...

A MULTINATIONAL cohort study of 4,592 individuals has revealed significant sex and ancestry-based differences in how the APOE-ε4 gene influences Alzheimer’s disease biomarkers, with women of African ...

Additionally, there remains a genetic risk factor in both diseases. The lipid transport protein called Apolipoprotein E ...

Neurofilament light chain and glial fibrillary acidic protein level increases were associated with cognitive decline in T2D with obesity.

The Indian e-commerce industry is projected to reach US$ 325 billion by 2030, experiencing significant growth. * Third-party logistics providers are anticipated to manage approximately 17 billion ...

A new study found 16 new genes that are likely linked to Alzheimer's risk. Here's everything to know about the study plus ...