Research in the past few years has uncovered two antiviral innate immunity pathways leading to the induction of interferons. The TLR pathway operates mainly in pDCs to detect viral RNA and DNA ...

Understanding the complex function of defensins in innate immunity against viral infection has implications for the prevention and treatment of viral disease. Figure 1: Induction of defensin ...

"Interferons are a central component of the innate immune system and combat viral infections by activating hundreds of antiviral genes in cells. This likely enables bats to control viral ...

Many viral infections are nipped in the bud by ... produce an interferon response and thus do not possess a classical innate immunity. This makes sense, says Voinnet, as the interferon response ...

While the viral 2’,5’-PEs antagonize innate immunity and thus promote viral replication, the mammalian AKAP7 does not have this function. Besides the antiviral function, these enzymes also ...

and the suppressive role of SMYD3 in antiviral innate immunity depended on its enzymatic activity. The knockout of SMYD3 or the inhibition of its enzymatic activity enhanced antiviral gene ...

Innate antiviral immunity includes secretion of type I interferons, antiviral cytokines, and certain cellular responses, including neutrophils, monocytes and macrophages, dendritic cells ...

Interestingly, the viral RNA-induced expression of type ... previously unrecognized concept that MET-mediated proliferation and innate immunity were closely interacted via LECT2-MET.

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.