More than 80% of early human embryos contain cells with an incorrect number of chromosomes—a phenomenon called aneuploidy. This typically stems from errors in chromosome segregation during the very ...

Former President Joe Biden and his late son actively chose to conceal details and misled the public regarding Beau Biden's cancer diagnosis while he served as attorney general of Delaware ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aneuploidy is prevalent in cancer and ...

of histone gene alterations linked to aneuploidy in cancers of the The Cancer Genome Atlas project. 1 Structural and functional features of histones and histone variants In this review, we focus on ...

This aberration, previously considered a consequence of genomic instability, is now recognized as a potential driver of cancer development. Dr Suruchi Aggarwal, PhD (Human Genomics), Lead, Scientific ...

Researchers used CRISPR technology to remove entire chromosomes in melanoma, gastric cancer, and ovarian cell lines Eliminating aneuploidy compromised cancer cells' ability to form tumors ...

Healthy human cells have 23 pairs of chromosomes, but it’s been observed for over a century that the majority of cancer cells have extras. This condition is known as aneuploidy, but its exact ...

But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells' fast growth. Such large-scale changes in DNA have been ...

Despite the detrimental consequences of aneuploidy for fitness in normal cells, it constitutes a hallmark in cancer, thus creating a paradox as its contribution to tumorigenesis. The study of the ...