Amyloid β (17 - 42) 是一种由 26 个氨基酸残基组成的多肽片段，属于 β- 淀粉样蛋白家族。在生理状态下，它通常以单体形式存在，具有一定的柔性结构。然而，随着浓度升高或在特定环境条件下，该多肽会发生聚集。其聚集过程起始于单体间通过疏水相互作用以及 ...

The therapies encourage cleaning cells called microglia to attack the clumps of amyloid-beta proteins that are thought to be involved in neurodegeneration. Microglia responses to amyloid beta can lead ...

While misfolded SOD1 proteins (among others) cause ALS, misfolded amyloid beta oligomers cause Alzheimer's disease. "These are good proteins gone bad," Klein said. "They are good proteins ...

Continuous treatment led to greater changes in plasma amyloid-beta 42/40 levels, reported Christopher van Dyck, MD, of Yale University in New Haven, Connecticut, in a poster presented at the ...

“Amyloid-beta, we think, is just a reaction. It’s a distraction. We have to be focusing on the root cause,” said Griffith University’s Professor James St John, who published a call for ...

Credit: Lightspring / Shutterstock. At the AD/PD 2025 International Conference on Alzheimer’s and Parkinson’s Diseases (AD/OD), during the ‘Abeta Targeting Therapies in AD’ symposium on 3 April, Roche ...

CD47 is found to play a pivotal role in this immunosuppression by inducing the production of amyloid-β (Aβ), which interacts with CD74 on B cells, leading to B-cell suppression and subsequent adaptive ...

And by the time the first symptoms develop, levels of abnormal amyloid-beta are almost peaking, forming clumps called plaques that clog up brain cells. Illustration of amyloid plaques. (Science Photo ...

That view is informed by data on the first wave of successful anti-amyloid-beta antibodies. Roche is hoping to improve on those molecules by pairing its antibody with technology for crossing the ...

相关文献 Mokhtar S H, Bakhuraysah M M, Cram D S, et al. The beta - amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton [J]. International Journal of ...