For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China SKL of ...

The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, offering a non-invasive, precise, and safe alternative to traditional DBS.

that binds to the hydrophobic domain of the non-amyloid-β component of α-synuclein, facilitating the degradation of α-syn fibrils. Using an α-syn fibril-induced PD model, the researchers ...

that binds to the hydrophobic domain of the non-amyloid-β component of α-synuclein, thereby degrading α-syn fibrils. Using α-syn fibril-induced PD model, researchers aimed to restore the ...

IL-10–secreting B lymphocytes and peritoneal macrophages are activated by immunization with amyloid fibrils composed of short peptides resulting in reduction of paralysis and inflammation in mice with ...

Researchers have long known fibrils—tiny tendrils assembled from invisibly small building blocks called amyloid proteins—are connected to a number of neurodegenerative diseases. But important ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

This study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) ...