For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

Controlling anisotropic droplet shapes on heterogeneous surfaces is crucial for many industrial applications, yet a robust model for precisely depicting these highly anisotropic shapes remains ...

The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

Arctic therapeutics raises funding from EIC Fund, Kaldbakur, and Sanos Group to advance its dementia treatment, AT-001, and acne drug, AT-004. The company aims to transform the treatment landscape for ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, ...

Computational biophysics uses numerical algorithms to study the physical principles underlying biological phenomena and processes. It provides a means of approximating solutions for theoretical ...

15, 2025 — Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel ...

Researchers developed a wireless photothermal nanosystem using gold nanoshells to stimulate thermosensitive TRPV1 receptors ...

A research team led by Prof. CHEN Chunying from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences designed a wireless photothermal DBS nanosystem, Au@TRPV1@β-syn ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The main weaknesses of this work results from the fact that only up to 70% of the tau fibrils form the desired fibril polymorphs. In addition, some of the figures are of low quality and confusing.