Allosteric ligands have been found to present a generally reduced side effect profile compared to orthosteric ligands but often suffer from reduced efficacy. (17,20) To overcome this problem, a new ...

† Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, Dk-2200 Copenhagen, Denmark ‡ Department of Physics ...

Scientists have unlocked new details on important receptor proteins—promising targets for the creation of novel drugs for ...

Contributed by J. Andrew McCammon, July 27, 2016 (sent for review June 24, 2016; reviewed by Richard J. Lewis and Jung-Hsin Lin) ...

For model benchmarking, Gcoupler was validated on GPCRs from the DUD-E dataset, alongside the information about the active ligands and their randomly selected number-matched decoys (35). Additionally, ...

Scientists have unlocked new details on important ‘receptor’ proteins –promising targets for the creation of novel drugs for ...

Contributed by Russell A. DeBose-Boyd; received December 18, 2024; accepted April 11, 2025; reviewed by Peter Espenshade and Randolph Y. Hampton Mutations in the gene encoding UbiA prenyltransferase ...

For more than a century, carbon monoxide (CO) has been primarily studied as a toxic substance that interferes with oxygen delivery to tissue beds. This dogma has changed in recent years, whereby ...

Explore GPCR-targeting therapies and their untapped potential in drug development, making up 30-35 percent of approved drugs.