for monomer ensemble movements (Figure S7); DCCM for enzyme–substrate complex and product glycosyl enzyme state (Figure S8); propeptide length distribution of endo-β-1,4-xylanases (Figure S9); ...

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, Lewis-Sigler Institute for Integrative Genomics, Princeton, New Jersey 08544, and Department of Chemistry, Boston College, ...

Beyond its enzymatic role, UBIAD1 serves as a key regulator of the endoplasmic reticulum (ER)-localized enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in the ...

The authors present a computational pipeline for the identification of endogenous allosteric modulators of GPCRs, with experimental validation performed in a yeast system. This approach is valuable ...

We demonstrate that the PgaCD machinery is a novel type c‐di‐GMP receptor, where ligand binding to two proteins stabilizes their interaction and promotes enzyme activity. This is the first example of ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) have now derived universal ...

The enzyme electrode is a miniature chemical transducer which functions by combining an electrochemical procedure with immobilized enzyme activity. This particular model uses glucose oxidase ...

Assembly instructions for enzymes Universal rules can help to design an optimal enzyme from scratch Date: May 23, 2025 Source: Max Planck Institute for Dynamics and Self-Organization Summary: In ...

Liver enzymes help the liver perform these functions by speeding up chemical reactions. Elevated liver enzymes happen when there are higher-than-normal levels of liver enzymes in your blood.

Neurosterix has stepped out of the shadows with $63 million from a first-round financing led by life sciences investment group Perceptive Advisors that will be used for a portfolio of allosteric ...