Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

The cellular process of macroautophagy/autophagy is implicated in the pathogenesis of GD and other thyroid diseases. Autophagy plays a critical role in many thyroid diseases and in different stages of ...

A study published by the Journal of Traditional and Complementary Medicine and e-published by the U.S. National Library of ...

Please view our affiliate disclosure. Trading involves risk which may result in the loss of capital. Akash Network (AKT) is built to function as a decentralized cloud computing network. This service ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

产品活性：Capivasertib (AZD5363) 是一种口服有效的 pan-AKT 激酶抑制剂，抑制 Akt1，Akt2 和 Akt3，IC50 分别为 3，7 和 7 nM。 体外：Capivasertib 是一种新型吡咯并嘧啶衍生化合物，可抑制所有 AKT 亚型，效力为 10 nM 或更低。Capivasertib 可抑制这些底物的磷酸化，在 3 种细胞系 ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China ...