BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

NUCKS1 regulates the invasion and metastasis of CRC via the HDAC2/AKT signaling pathway 蛋白质组学筛选出643个差异蛋白，其中HDAC2与NUCKS1表达呈正相关。机制研究表明，NUCKS1过表达使HDAC2和磷酸化AKT(p-AKT Ser473 ...

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路是细胞内重要的信号传导通路之一，该通路的异常激活在多种疾病特别是恶性肿瘤中发挥着关键作用。近年来，靶向 PI3K/AKT/mTOR ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Such a cobblestone tongue is a telltale sign of a rare genetic condition called Cowden syndrome. It's caused by inherited ...

Kazia Therapeutics ( ($KZIA) ) just unveiled an update. On June 5, 2025, Kazia Therapeutics announced the dosing of the first patient in a Phase ...

OS involves complex crosstalk among multiple signaling pathways, and the multi-target nature of traditional Chinese medicine metabolites suggests broader mechanistic interactions. Although our ...

PI3K/AKT 信号通路参与调节细胞的糖代谢 ... 图. BZA-enhanced 5-FU-induced cell apoptosis is partly related to the Bad/Bcl-2 signaling pathway in colon cancer HT29 and SW480 cells ...

Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, People’s Republic of China The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, ...