Diseases associated with mechanosensitive adhesion G protein-coupled receptors ... As a distinct subgroup of the GPCR superfamily, aGPCRs possess a specialized extracellular domain, enabling ...

(A) The basic structure of aGPCRs. This article highlights the critical role of mechanosensitive aGPCRs in human health and disease, setting the stage for future research into mechanotransduction ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists ...

Problems with aGPCRs can also lead to diseases like cancer ... This opens up new opportunities for drugging adhesion GPCRs, because now we are showing that the extracellular region is ...

Bone Marrow Transplantation Center of the First Affiliated Hospital, Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China. State Key Laboratory of ...

Mutations in adhesion GPCRs had been found to associate with human diseases and knockout animals exhibit a variety of defects further supporting their functional importance during development and ...

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling ...

Adhesion GPCRs belong to the large family of G protein ... researchers in this field to gain a deep understanding of human diseases, because the animals are genetically very similar to humans.

Adhesion GPCRs are a group of G protein-coupled receptors associated with many bodily functions and diseases in humans. Scientists at Leipzig University have discovered a new receptor—which they ...