The family of adhesion G protein-coupled receptors (aGPCRs) represents the second largest class of GPCRs, and aGPCRs have ... for human health and disease. In this Review, we discuss the current ...

山东大学基础医学院孙金鹏和于晓教授团队在Nature杂志分别以 “Structural basis for the tethered peptide activation of adhesion GPCRs”和“Tethered peptide activation mechanism of the adhesion GPCR ADGRG2 and ...

(A) The basic structure of aGPCRs. This article highlights the critical role of mechanosensitive aGPCRs in human health and disease, setting the stage for future research into mechanotransduction ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists ...

Diseases associated with mechanosensitive adhesion G protein-coupled receptors ... As a distinct subgroup of the GPCR superfamily, aGPCRs possess a specialized extracellular domain, enabling ...

the adhesion GPCRs (aGPCRs), is still uncharted pharmacological and pharmaceutical territory. These molecules are associated with a wide range of diseases, from cancer to psychiatric disorders ...

Adhesion GPCRs belong to the large family of G protein ... researchers in this field to gain a deep understanding of human diseases, because the animals are genetically very similar to humans.

This genetic disease causes fluid-filled cysts to form in the kidneys and other organs ... Generic residue numbering of the GAIN domain of adhesion GPCRs. Nat Commun. 2025;16(1):246. doi: ...