With the discovery that APP mutations can act as fully penetrant AD genes, a compelling hypothesis known as the amyloid cascade hypothesis was put forward. This hypothesis states in essence that ...

“GFAP positivity could help us identify people with brain amyloid who are fated to develop tau pathology,” Pascoal told Alzforum. In preclinical AD, tau phosphorylation ... burden correlate with ...

An estimated 50 million people around the world have Alzheimer's disease (AD), and perhaps twice that number are unknowingly "incubating" the disease during its long presymptomatic period.

Soon after Clifford Jack, Mayo Clinic, Rochester, Minnesota, proposed a hypothetical model showing biomarkers emerging at different stages of Alzheimer’s disease (AD), his diagram ... does not ...

32 Tau tangles and amyloid plaques are not the only features observed in the AD brain; inflammation and oxidative stress also occur. The mitochondrial cascade hypothesis indicates that tau and Aβ ...

Screening the literature, it may appear that for many in the AD field, the ultimate proof to be right after following the mainstream hypothesis (the "amyloid cascade") for decades is of top ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

Wang’s study “β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade,” was recently published ... Alzheimer’s disease (AD) is a devastating disease that affects ...

A genetic predisposition for Alzheimer's disease (AD) has been ... note. Amyloid-beta has demonstrated epileptogenic potential, even in early stages of the amyloid cascade. On the other hand ...

It's hypothesized that in AD, amyloid triggers a cascade of events, starting with an increase in phosphorylation of tau, then accumulation of neurofibrillary tangles, with the amyloid and ...

An estimated 50 million people around the world have Alzheimer’s disease (AD), and perhaps twice that number are unknowingly “incubating” the disease during its long presymptomatic period.