Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...

This work presents a pioneering biosensor that combines a bottom-up design approach using paper as a platform for the electrochemical recognition of peptide amyloid β-42 (Aβ-42), a biomarker for AD ...

In this Review, we consider recent evidence implicating intracellular Aβ in the pathogenesis of AD, including its relationship to extracellular amyloid plaques as well as its effects on synaptic ...

Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, U.K.

The extent of myocardial bone tracer uptake with technetium pyrophosphate, hydroxymethylene diphosphonate, and 3,3-diphosphono-1,2-propanodicarboxylate in transthyretin amyloid cardiomyopathy (ATTR-CM ...

Astrocyte-derived APOE and microglia: Astrocyte-derived APOE could induce fibrillar amyloid plaques even without the presence of microglia, although to a lesser extent. The APOE4 allele increases the ...