In this Review, we consider recent evidence implicating intracellular Aβ in the pathogenesis of AD, including its relationship to extracellular amyloid plaques as well as its effects on synaptic ...

In vitro structural studies have shown that misfolding and aggregation involve a large structural rearrangement of the protein, forming cross-β amyloid ... diseases (AD, PD, HD, TSE and ALS ...

This work presents a pioneering biosensor that combines a bottom-up design approach using paper as a platform for the electrochemical recognition of peptide amyloid β-42 (Aβ-42), a biomarker for AD ...

Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge CB2 1EW, U.K.

In the future molecular diagnostic indices such as CSF Aβ1–42 or amyloid PET scanning may increasingly be used to confirm or exclude the presence of AD (amyloid) pathology in these cases. Clinical ...

Tornadoes were spotted Friday afternoon in the St. Louis area and above southern Illinois, prompting weather officials to implore people in the region to take cover. National Weather Service radar ...