Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change. Chemistry & Biology , 2013; 20 (5): 701 DOI: 10.1016/j.chembiol.2013.03.019 ...

The motion of motor proteins on biopolymers is important for diverse biological processes. Actin, microtubules, and nucleic acids can serve as one-dimensional tracks on which motor proteins move.

What was seen in the Arp2/3 complex, Nolen said, will help to understand precisely how actin is controlled in cells. "Cell motility requires actin inside the cell to constantly be remodeled," he said.

Actin filaments are protein fibers that make up the internal skeleton of the cell. As active elements of our cells, actin filaments support the cell’s fusion, movement and are involved in many other ...

Gamma-actin therefore confers increased rigidity to the apical membrane, forming a network of filaments that is stronger and stiffer than that made up of beta-actin filaments.

Vimentin, a protein that forms filaments within cellular cytoskeletons, is critical in helping cells keep their shape and maintain mechanical stability. Additionally, vimentin plays an important ...

Actin filaments — protein structures critical to living movement from single cells to animals — have long been known to have polarity associated with their physical characteristics, with growing ...