Visualization of TRPV1, the protein that plays a central role in the perception of pain and heat. From Liao et al., Nature 504, 107–112, 2013 Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu ...

In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

Structure of key pain-related protein unveiled. ScienceDaily. Retrieved June 1, 2025 from www.sciencedaily.com / releases / 2013 / 12 / 131204132022.htm. University of California - San Francisco.

In a technical tour de force, UC San Francisco scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

The structure of a protein that plays a central role in the perception of pain and heat has been unveiled by UC San Francisco (UCSF) scientists. Led by UCSF postdoctoral fellows Erhu Cao, PhD, and ...

In a technical tour de force, scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat. ... Structure of Key ...

Led by UCSF postdoctoral fellows Erhu Cao, PhD, and Maofu Liao, PhD, the new research will offer fresh insights to drug designers searching for new and better pain treatments, but it also is a ...

Known as TRPV1, the protein was discovered more than 15 years ago. Although scientists knew that it could sense heat and various chemicals, exactly how it worked remained a mystery. In December, ...

The primary structure of a protein — its amino acid sequence — drives the folding and intramolecular bonding of the linear amino acid chain, which ultimately determines the protein's unique ...

“If we identify temperature-sensitive domains and determine how they are involved in protein unfolding, we could also leverage this knowledge to potentially engineer temperature-responsive proteins ...

Once it was fully trained, ESM-2 was able to ingest a raw string of amino acids and output a 3D protein structure, along with a score that represents its confidence in the accuracy of that structure.