Ltd. have synthesized azetidine-containing compounds acting as muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, asthma, pain ...

This study presents a valuable finding on the role of cholesterol-binding site on GLP-1 receptors and functionally characterizes the impact of this mutation on receptor behavior in the membrane and ...

"The main issue with understanding these interactions is that there is a competition between an ion binding to a certain receptor and that same ion wanting to be surrounded by solvent molecules ...

The nicotinic acetylcholine receptors (nAChRs ... The acetylcholine (ACh)-binding sites on the nAChR are located in the extracellular domain at subunit boundaries, and their structure and drug ...

72076 Tübingen, Germany Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of ...

The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR. While the active structure of the C3a-C3aR ... reveals that JR14a engages in ...

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill, Indianapolis, Indiana46202-3082, United States ...

Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a retrospective postmortem brain ...

After 30 s, drugs were applied, and the following 120 s were defined as the drug response period for analysis. Data reported for α7 were net charged, while peak currents were used for α9 and α9/α10 ...

The habenular-IPN circuit is rich in receptors for ... mutant mice suggesting that acetylcholine helps the release of glutamate from habenular nerve endings. Frahm, Antolin-Fontes, Görlich et al. then ...